Neuroscience Identification of Spinal Circuits Transmitting & Gating Mechanical Pain Questions

Neuroscience Identification of Spinal Circuits Transmitting & Gating Mechanical Pain Questions

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Q1) Why would you expect that the C-fiber evoked EPSC (Excitatory Post Synaptic Current) peak is slower than the A-delta in Fig 2f?
Q2) How is the behavioral result in Figure 4 different from the behavioral result in Figure 2?
Q3) What did the authors find with respect to the DYN ablated animals’ response to noxious heat/cold? Is that surprising (why/why not)?
Q4) How do the SOM and DYN cells fit into the ‘Gate Theory’ model as it applies to mechanical allodynia?
Does this paper support the specificity theory or pattern theory of pain
Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC42585…

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